Fluorinated molecules as drugs and imaging agents in the CNS
S Sun, A Adejare - Current topics in medicinal chemistry, 2006 - ingentaconnect.com
S Sun, A Adejare
Current topics in medicinal chemistry, 2006•ingentaconnect.comThe strategic use of fluorine substitution in drug discovery and drug development is well
documented. The small size and high electronegativity of fluorine are among properties of
this element that lend special advantages. Applications in drugs targeted to the central
nervous system (CNS) have been particularly fruitful in addition to favorable properties seen
in many peripherally acting drugs. Fluorine substitution can be used to solve problems
unique to the CNS, such as blood brain barrier (BBB) penetration. Likewise, use of the …
documented. The small size and high electronegativity of fluorine are among properties of
this element that lend special advantages. Applications in drugs targeted to the central
nervous system (CNS) have been particularly fruitful in addition to favorable properties seen
in many peripherally acting drugs. Fluorine substitution can be used to solve problems
unique to the CNS, such as blood brain barrier (BBB) penetration. Likewise, use of the …
The strategic use of fluorine substitution in drug discovery and drug development is well documented. The small size and high electronegativity of fluorine are among properties of this element that lend special advantages. Applications in drugs targeted to the central nervous system (CNS) have been particularly fruitful in addition to favorable properties seen in many peripherally acting drugs. Fluorine substitution can be used to solve problems unique to the CNS, such as blood brain barrier (BBB) penetration. Likewise, use of the positron emitting isotope, 18F, provides a unique tool for non-invasive imaging and diagnoses in the CNS. In this review, fluorine in CNS drugs and drug discovery are discussed.
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